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Therefore, an increased supply of Met may increase antioxidant production, potentially aiding in the relief of oxidative stress and inflammation triggered by the production of reactive oxygen metabolites ( Conversely, Hcy has the capacity for remethylation to regenerate methionine, which relies on the folate cycle and vitamin B 12 ( Figure 1 ) ( 2 -THF), which is subsequently reduced to 5-methyltetrahydrofolate (5-CH 3 -THF) (Preynat et al., 2009)

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H-iJ, Y-HK, M-SK, B-RL, T-HK, E-JL, G-BJ, M-JC, C-HL, and J-KS analyzed the data and provided constructive comments and comprehensive discussion on the manuscript